Biological Activities of Chlormadinone Acetate (III)
نویسندگان
چکیده
منابع مشابه
[Biological activities of chlormadinone acetate. (I). Analysis of hormonal activities].
Biological activities of 17a-acetoxy-6-chloro-pregna-4,6-diene-3,20-dione (chlormadinone acetate ; CMA) were investigated in comparison with those of 17a-acetoxy-6a-methylpregnane-3,20-dione (medroxyprogesterone acetate ; MAP). CMA produced marked progestational activity either subcutaneously or orally in the uterine carbonic anhydrase test, and its relative potency is approximately 30 times th...
متن کاملEffects of post-coital administration of chlormadinone acetate to rats.
Different doses (ranging from 31 to 1000 \g=m\g)of chlormadinone acetate were injected into female rats on Days 2 to 6 ofpregnancy. The percentage of ova lost before implantation increased with higher doses of the drug, whereas the implantation ratio (number of rats with implantations/total number of rats) was not affected by treatment. The dose of 1 mg altered the onset ofparturition in 50% of...
متن کاملEthinylestradiol/Chlormadinone acetate for use in dermatological disorders.
The diagnosis and management of four cases of dermatological disorders, most of which are related to the endocrine disorder of androgen excess, are presented. Combined oral contraceptives (COCs) may be useful when well-tolerated hormonal therapy and/or when contraception is required. A female patient with androgenetic alopecia or female pattern balding, without underlying hyperandrogenism, was ...
متن کاملContraception with chlormadinone acetate in woman with previous contraceptive jaundice.
The oral contraceptive chlormadinone acetate has been given for eight months to a woman who had developed jaundice during four pregnancies, and twice while taking a combined contraceptive pill. No side-effects or changes in liver function were observed. This is further evidence that progestogens used for contraception, and in particular those derived from hydroxyprogesterone, are less hepatotox...
متن کاملEffect of chlormadinone acetate, a synthetic progesterone, on hypoxic ventilatory response in men.
Ten healthy young males were studied with a double-blind, cross-over trial to determine whether or not chlormadinone acetate (CMA), a potent synthetic progesterone, augments hypoxic chemosensitivity. Seven days after CMA administration, inspiratory minute volume (VI) and tidal volume (VT) significantly increased. PaCO2 decreased by 3.0 +/- 2.6 (S.D.) Torr (p less than 0.05) and plasma bicarbona...
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ژورنال
عنوان ژورنال: Folia Endocrinologica Japonica
سال: 1966
ISSN: 0029-0661
DOI: 10.1507/endocrine1927.42.2_140